Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells
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چکیده
منابع مشابه
Bcl-2 Over-Expression and Genetic Manipulation of T Cells Provides Tumor Specificity and Enhanced Resistance to Apoptosis In Vitro
Adoptive immunotherapy using T cells has produced some encouraging clinical responses, but deficiencies resulting from a frequent lack of tumor specificity and poor survival of these cells has limited the widespread application of this approach. We used a chimeric receptor gene specific for erbB2 in T cells with genetic resistance to apoptosis to address these deficiencies. Expression of the ch...
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Chronic inflammation drives the development of atherosclerosis. Dendritic cells (DCs) are known as central mediators of adaptive immune responses and the development of immunological memory and tolerance. DCs are present in non-diseased arteries, and accumulate within atherosclerotic lesions where they can be localised in close vicinity to T cells. Recent work has revealed important functions ...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2011
ISSN: 2041-4889
DOI: 10.1038/cddis.2010.91